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Aptilon Corporation Announces Graduation to Tier 1 
of the TSX Venture Exchange

Aptilon Corporation recognized among advanced Issuers 
with the most significant financial resources.

Montreal, Quebec, June 19, 2007 Aptilon Corporation (“Aptilon” or the “Corporation”) (TSX-V: APZ), announces that the TSX Venture Exchange has conditionally approved its graduation from a Tier 2 Issuer to a Tier 1 Issuer. Tier 1 is the Exchange’s premier tier and is reserved for the Exchange’s most advanced Issuers with the most significant financial resources. This graduation will result in the immediate release of 17 088 382 common shares held mainly, directly or indirectly, by principals of Aptilon or its subsidiary, and an acceleration of the release schedule of the 34 176 779 common shares remaining in escrow pursuant to the escrow agreements entered into at the time of Aptilon’s initial public offering in 2005 and of its qualifying transaction in December 2006.

“We are pleased to announce this graduation of Issuer status to Tier 1 of the TSX Venture Exchange” stated Denis Martineau, President. “With the outstanding efforts and dedication of our employees and business advisory teams Aptilon continues to strengthen its business, and improve its overall outlook.” he continued.

About Aptilon Corporation
Aptilon enables pharmaceutical, biotech, and medical device companies to effectively reach and interact with physicians via the Internet through its innovative live video detailing (with company reps), e-detailing, e-sampling, peer selling, and other educational content programs. Leading healthcare companies have adopted Aptilon’s “Sales Force of the Future” model, driving tens of thousands of high-quality rep-physician interactions averaging 8 to 10 minutes in length. Aptilon provides the necessary infrastructure for sales representatives to build physician awareness, understanding, and preference during all stages of a product life cycle, from pre-launch education through to end-stage support. For more information, visit www.aptilon.com.

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The TSX Venture Exchange has neither approved nor disapproved the contents of this press release. The TSX Venture Exchange does not accept responsibility for the adequacy or accuracy of this press release.

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