Aptilon Corporation Announces Grants of Options

Montreal, Quebec, December 24, 2007 - Aptilon Corporation (the “Corporation”) (TSX Venture Exchange: APZ), a leading provider of physician access through its innovative alternative sales and marketing channel, announces that, on December 21, 2007, it has granted an aggregate of 1,300,000 options to 19 of its employees and consultants. None of these options were granted to directors or officers of the Corporation. These options have an exercise price of $0.25 per share and a five year term and are subject to the terms and conditions of the Corporation's stock option plan.

About Aptilon Corporation
Aptilon enables pharmaceutical, biotech and medical device companies to effectively reach and interact with physicians via the Internet through its innovative AxcelRx Live video detailing (with company reps), virtual programs, peer selling and other sales and marketing programs.  Leading health care companies have adopted Aptilon’s model, driving tens of thousands of high-quality rep-physician interactions averaging more than eight minutes in length. Aptilon provides the infrastructure necessary for sales representatives to build physician awareness, understanding and preference during all stages of a product’s life cycle, from pre-launch education through end stage support.  For more information, visit www.aptilon.com.

Forward-looking Statements
This news release contains forward-looking information. These statements relate to future events or future performance and reflect management's current expectations and assumptions. Such forward-looking statements reflect management's current beliefs and are based on information currently available to management of Aptilon. A number of factors could cause actual events, performance or results to differ materially from the events performance and results discussed in the forward-looking statements. These forward-looking statements are made as of the date hereof and Aptilon does not assume any obligation to update or revise them to reflect new events or circumstances.