Med AD News Selects Aptilon as one of the Pharmaceutical 
Ventures to Watch

Montreal, Quebec, December 18, 2008 - Aptilon Corporation (“Aptilon” or the “Company”) (TSX-V: APZ), a leader in creating online access to physicians for pharmaceutical sales programs, announced that it has been chosen by Med Ad News, a leading worldwide industry journal for 25 years, as one of the Pharmaceutical Marketing Ventures to Watch. Each year, Med Ad News seeks out the companies that are providing the most innovative and interesting products, services or marketing opportunities to pharmaceutical companies in the health care community. It makes its selections after reviewing dozens of nominations.

Aptilon was singled out for its development of its unique AxcelRx^SM video detailing platform, now subscribed to by half of the top 12 US pharmaceutical companies. The announcement comes at a time when Aptilon's clients are renewing and expanding their projects for 2009.

"One of the fundamental principles behind Aptilon's video detailing platform is convenience for physicians. Rather than having to make time for sales reps whenever they happen to appear at a practice, the physician can schedule a video detail with a rep at any time that is convenient."

Med Ad News went on to say, "Aptilon's platform goes well beyond the traditional detail in other ways. The company wants physicians to look at its service as a complete information resource for everything from a quick question to an in-depth clinical review."

Mark Benthin, Aptilon's COO commented, "One of the key reasons why the top US pharmaceutical companies are adopting our AxcelRx platform is the comprehensive suite of activities we offer physicians from the initial video encounter. A live internet dialogue between the sales representative and physician takes place at the most convenient time for the physician. As our survey data repeatedly confirms, the live interactions are also highly productive for physicians, who can leverage a wide range of information online. Live video attracts the physician to the initial online encounter, which becomes the gateway for our other interactive services, such as viewing key opinion leader (KOL) presentations, conducting patient case studies and ordering drug samples online."

Mr. Benthin continued, "AxcelRx is the new interactive space for physicians and pharmaceutical sales representatives to meet. It is the destination for the physicians we attract through our Reachnet^SM recruiting services, a high impact identification and recruiting system powered by database profiling data on more than 450,000 US physicians. Through Reachnet, we are able to recruit leading physicians to engage with pharmaceutical representatives in high quality interactions lasting 8-15 minutes, thereby generating significant promotional efficiencies for pharmaceutical companies."

Med Ad News noted, "Executives with Ortho McNeil Neurologics Inc., say Aptilon's alternative sales channel, AxcelRx, is a key component of the model that will enable the company's representatives to provide convenient concierge-type services with education to physicians. Ortho-McNeil was one of the first clients for AxcelRx after the product was launched to the general market in 2007."

"The pharmaceutical industry is evolving from mass marketing to relationship marketing," says Greg Mattle, manager of e-marketing, Ortho-McNeil Neurologics. "AxcelRx Live enables us to make our brand information and services available to physicians in a way that's meaningful and impactful. Our commitment to this area is significant."

 About Aptilon Corporation

Aptilon enables pharmaceutical, biotech and medical device companies to effectively reach and interact with more than 450,000 US physicians via the Internet through its innovative AxcelRx Live video detailing platform which hosts promotional, peer selling and other sales and marketing programs. Top US healthcare companies have adopted Aptilon’s AxcelRx Live solution for their sales representatives to reach leading physicians online. Aptilon provides the infrastructure necessary for pharmaceutical companies to build physician awareness, understanding, and product preference during all stages of a product’s life cycle, from pre-launch education through end stage support. For more information, visit www.aptilon.com.

AxcelRx^SM and ReachNet^SM are service marks of Aptilon Corporation.

Forward-looking statements

This news release contains forward-looking information. These statements relate to future events or future performance and reflect management's current expectations and assumptions. Such forward-looking statements reflect management's current beliefs and are based on information currently available to management of Aptilon. A number of factors could cause actual events, performance or results to differ materially from the events performance and results discussed in the forward-looking statements. These forward-looking statements are made as of the date hereof and Aptilon does not assume any obligation to update or revise them to reflect new events or circumstances.

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